Break the Chains of Dependence
You're not alone. Thousands of people are navigating kratom and 7-OH withdrawal right now. We've built the tools, community, and resources to support you on your journey forward—at your own pace. We're in recovery ourselves. SR-17018 has helped free many of our customers who were daily 7-OH and kratom users for years.
For Research Use Only. SR-17018 is NOT intended for human or veterinary use. Supplied exclusively for legitimate scientific and academic research.
The Compound
What Is SR-17018?
SR-17018 (CAS 2134602-45-0) is a synthetic, G-protein biased mu-opioid receptor agonist originally developed at the Scripps Research Institute. Unlike conventional opioids, it selectively activates G-protein signaling pathways while minimizing beta-arrestin recruitment — a profile associated with reduced tolerance development in preclinical models.
Researchers have investigated SR-17018 in the context of opioid dependence, kratom alkaloid tolerance (including 7-hydroxymitragynine / 7-OH), and withdrawal symptom models. Supplied exclusively as a research compound.
Compound Specifications
| CAS Number | 2134602-45-0 |
| Purity | ≥99% (HPLC verified) |
| Form | Fluffy Powder — Pinkish Hue to Off-White/Beige |
| Molecular Weight | ~400 g/mol |
| Receptor Target | μ-Opioid Receptor (MOR) |
| Mechanism | G-protein biased agonist |
| Storage | Cool, dry, light-protected |
| Analysis | 3rd-party per batch |
| COA | Included with every order |
Research Context
If You're Here, You Already Know Why
Most people researching SR-17018 aren't doing it out of academic curiosity. They're looking for a way out of something — kratom, 7-OH, opioids — that's harder to stop than they expected.
Kratom Hooks You the Same Way Opioids Do
7-hydroxymitragynine — the active metabolite your body makes from kratom — is a full opioid agonist. Not "opioid-like." An actual opioid, hitting the same receptor as morphine. The dependence that follows is real, the withdrawal is real, and "just stopping" works about as well as it does with any opioid.
Read the researchWhy Your Body Fights Back When You Try to Quit
Every time you dose, beta-arrestin signals your receptors to downregulate — your brain physically reducing its sensitivity to compensate. By the time you try to stop, your nervous system has rebuilt itself around the drug being there. That's not weakness. That's biology.
Understand the mechanismWhat Makes SR-17018 Different for Taper Research
SR-17018 activates the same mu-opioid receptor — but skips the beta-arrestin step that drives tolerance and downregulation. Preclinical models show it can occupy receptors without compounding the dependency problem. That's why researchers use it as a taper tool.
Read the dosing guideWhy SR17Direct
Quality You Can Verify
Third-Party Tested
Every batch undergoes independent HPLC and NMR analysis. Full certificates of analysis included.
≥99% Purity
Research-grade synthesis verified by accredited laboratories. Consistent quality across every order.
Strict QC Standards
Manufactured following rigorous quality protocols. Full batch traceability for your records.
COA With Every Order
Transparent analytical documentation accompanies every shipment — no exceptions.
Crypto Payments
BTC, ETH, LTC, USDT, and XMR accepted for secure, private transactions.
Research Grade Only
Supplied exclusively for legitimate laboratory and scientific research applications.
Free Recovery Tools
Your Path to Zero.
One Day at a Time.
SR17Direct isn't just a supplier — we're a recovery resource. Our free, research-grounded tools help you plan and track an SR-17018-assisted taper.
Why a Taper Protocol Works
Calibration Phase
Start low to establish your baseline response before committing to a full protocol.
Maintenance Phase
Hold at a stable dose to allow your receptors to normalize before beginning reduction.
Taper Phase
Gradually reduce your dose on a schedule your body can adapt to — minimizing withdrawal.
All tools are free, require no account, and store no personal data. Your protocol stays on your device.
Community Experiences
What Researchers Are Saying
Anonymous accounts from the research community. Unverified. For informational purposes only.
"After struggling with a severe 7-hydroxymitragynine habit, I decided to try SR-17018 as a last resort. Within a week, I was completely free — with almost none of the withdrawal I had come to dread."
"I spent sixteen years cycling through various opioid dependencies. After using SR-17018 for just over a week, I was able to walk away from all of it. Two weeks later, I'm still clean."
"I had been on Suboxone for over a year and dreaded the idea of tapering. With SR-17018, I simply made the switch, used it for five days, and then stopped everything. A month later, I'm still free."
Before You Order
Questions, Answered
SR-17018 is an unscheduled research chemical in the United States. It is sold strictly for laboratory and research use — not for human or veterinary consumption. You are responsible for compliance with the laws of your own jurisdiction.
Get Started Today
Research-Grade SR-17018.
Recovery-Focused Tools.
Order analytically verified SR-17018 with COA included, or start with our free taper calculator — no account required.
For research use only · Not for human consumption · COA included with every order